To observe clinical efficacy of the combined Sun Shen-Tian scalp acupuncture and abdominal acupuncture treatment scheme on cognitive function decline in chronic fatigue syndrome. Methods: Ninety patients with chronic fatigue syndrome were recruited, and randomly divided into treatment group (n=45) and control group (n=45). Each group was respectively given routine treatment plus combined Sun Shen-Tian scalp acupuncture and abdominal acupuncture, and routine treatment plus standard electroacupuncture treatment. Both groups were treated with acupuncture once a day, 5 times a week, for 4 weeks. After treatment, the efficacy, FS-14 score, MoCA score, and time spent completing the MoCA were compared between the two groups, and a follow up was performed 6 months later. Results: After treatment, the efficacy in the treatment group was significantly higher than that of the control group (P<0.05). After 4 weeks of treatment, the FS-14 score, MoCA score, and MoCA completion time in the treatment group were significantly improved compared to those in the control group (P<0.05). At the 6-month follow-up, the FS-14 score, MoCA score, and MoCA completion time in the treatment group were still better than those in the control group (P<0.05). Conclusion: The Sun Shen-Tian scalp acupuncture and abdominal acupuncture combined treatment scheme has better clinical efficacy in improving the cognitive ability and reaction speed of patients with chronic fatigue syndrome, and this therapeutic effect remains stable with time.