To explore the relationship between depressive symptoms in college students and internet bullying, individual coping self-efficacy, and cognitive reappraisal. Methods: A total of 1 454 college students from two universities in Wuhan were investigated by the Revised Cyber Bullying Inventory, College Students Mental Health Screening Scale, Coping Self-efficacy Scale, and Emotion Regulation Questionnaire. Results: The detection rate of depressive symptoms in college students was 4.76%, and there was no gender difference. There was a significant positive correlation between the score of cyberbullying and the total score of depression (r=0.16, P<0.01), a significant negative correlation between coping self-efficacy and depression (r= －0.37, P<0.01), and a significant negative correlation between cognitive reappraisal and depression (r =－0.23, P<0.01). SPSS regression analysis showed that the mediating effect of coping self-efficacy between cyberbullying and depression accounted for 25.68% of the total effect, the mediating effect of cognitive reappraisal between cyberbullying and depression accounted for 5.71% , and the multiple mediating effect of coping self-efficacy and cognitive reappraisal between cyberbullying and depression accounted for 3.07% . Conclusion: Coping self-efficacy and cognitive reappraisal play multiple mediating roles in the relationship between cyber-victimization and depression in college students.