To evaluate the effect of group dynamic interpersonal therapy (DIT) on improving the interpersonal relationship of adolescent patients with anxiety and depression. Methods: A total of 120 adolescents with anxiety and depression were divided into the experimental group and control group by digital parity, with 60 patients in each group. Patients in the experimental group took Sertraline and received group DIT twice a week for 16 sessions. Patients in the control group were only treated with Sertraline. The Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Comprehensive Diagnostic Scale of Interpersonal Relationship (IRAS) scores were measured in both groups before and after treatment. After group therapy, the experimental group completed the Group Psychotherapy Efficacy Factor Questionnaire (GTFQ). Results: After group DIT, the total scores of the HAMA, HAMD, and IRAS and column Ⅰ, Ⅱ, and Ⅳ scores in the experimental group were significantly lower than those before treatment (P<0.01). The HAMA and HAMD scores in the control group decreased significantly after treatment (P<0.01), but the scores were higher than those in the experimental group. The highest scoring efficacy factor of group therapy was existential awareness. Conclusion: Not only can group DIT further reduce anxiety and depression, it can also effectively improve the interpersonal relationship of adolescent patients with anxiety and depression.