To observe the effect of blood flow restriction (BFRT) combined with low-intensity resistance training on muscle strength, physical fitness and activities of daily living in elderly patients with cerebral infarction complicated with sarcopenia. Methods: Seventy-one elderly patients with cerebral infarction complicated with sarcopenia were randomly divided into the observation group (35 cases) and control group (36 cases). The 2 groups were given low-intensity resistance training, and the observation group was given BFRT. Before training and 12 weeks after training, muscle strength was evaluated by grip strength, physical fitness was evaluated by the short physical performance battery (SPPB), and activities of daily living were evaluated by the modified Barthel Index (MBI); additionally, myopenia-related biomarkers including growth hormone (GH), insulin-like growth factor-1 (IGF-1), and interleukin-6 (IL-6) were detected. Results: After training, the grip strength, SPPB score, and MBI score of the observation group were higher than those of the control group (P< 0.01). The ASM, SMI and ASMI scores in the observation group were higher than those in the control group (P< 0.05 or P<0.01). The levels of GH and IGF-1 in the observation group were higher than those in the control group (P<0.01). The level of IL-6 in the observation group was lower than that in the control group (P<0.01). Conclusion: BFRT combined with low-intensity resistance training can improve the muscle strength, physical fitness, and activities of daily living of elderly patients with cerebral infarction and sarcopenia, improve the quality of skeletal muscle, promote the secretion of anabolic hormones, and reduce the level of inflammatory factors.