To evaluate the efficacy of low frequency-repetitive transcranial magnetic stimulation (rTMS) on anxiety and insomnia in patients with Parkinson’s disease (PD). Methods: 64 patients with PD combined with anxiety and insomnia were enrolled and randomly divided into treatment group and control group, 32 cases in each group. In addition to the conventional PD medication, patients in the treatment group received 1 Hz rTMS in the right dorsolateral prefrontal cortex (DLPFC), and patients in the control group received pseudo-magnetic stimulation in the same area. All the patients were treated for four weeks. The changes of motor function, anxiety state and insomnia before and after treatment were compared between the two groups. Results: There were no significant differences in the motor function PD-UPDRS- Ⅲ score, Hoehn-Yahr score, anxiety SAS score, sleep PSQI score between the two groups before treatment (P>0.05). After treatment, the above scale scores in the control group were not significantly different from those before treatment (P>0.05). The above scale scores in the treatment group were lower than those in the same group before treatment, and were lower than those in the control group after treatment (P<0.05). Conclusion: Low-frequency rTMS may help to improve the motor function and anxiety state of patients with PD complicated with anxiety and insomnia, and improve their sleep quality.