To investigate the effect of residual hematoma volume at the end of treatment (EOT) on the prognosis of intracerebral haemorrhage (ICH) patients after minimally invasive surgery (MIS). Meth? ods: A total of 256 ICH patients treated with MIS were enrolled. According to the prognosis of the patients after discharge, the ROC curve analysis showed that the cut-off value of residual hematoma volume at EOT was 11.288 mL. 119 patients were divided into low EOT residual hematoma volume group (residual intracranial hematoma volume＜11.288 mL) and 65 in high EOT residual hematoma volume group (residual intracranial hematoma volume≥11.288 mL). The demographic data, past history, clinical data and imaging data of all the patients were collected and analyzed. Results: Compared with the high EOT residual hematoma volume group, the low EOT residual hematoma volume group had a higher proportion of good prognosis and a lower proportion of mortality rate. The results of binary logistic regression and COX regression showed that residual hematoma volume<11.288 mL at EOT was an independent predictor of good prognosis. Conclusion: The residual hematoma volume less than 11.288 mL at EOT may be an independent predictor of good prognosis for ICH patients after MIS.