To explore the related factors affecting prognosis of patients with spontaneous cerebellar hemorrhage (SCH) treated by non-operative treatment. Methods: The clinical data of 105 patients with SCH treated by non-operative treatment were collected. According to their modified Rankin Scale (mRS) scores at 3-month follow-up, patients were divided into good prognosis group (mRS 0～3) and poor prognosis group (mRS 4～6). The clinical data of two groups were compared and analyzed. Results: 72 patients (68.4%) were in good prognosis group and 33 (31.3%) in poor prognosis group, of which 25 cases (23.8%) died. GCS score on admission, hematoma enlargement after admission, diameter of hematoma on admission, compression sign of posterior fossa and diabetes mellitus were independent predictors of poor prognosis for non-surgical SCH patients (P<0.05). The time-dependent ROC curve area of the admission GCS score was 0.929, and 12 points was the best cut-off value of admission GCS score; the time-dependent ROC curve area of the admission hematoma diameter was 0.820, and 3.6 cm was the best cut-off value of admission hematoma diameter. Conclusion: Admission GCS score<12, admission hematoma diameter>3.6 cm, posterior fossa contraction sign, enlargement of hematoma after admission and diabetes mellitus, lead to poor prognosis, which are independent risk factors affecting the 3-month prognosis of SCH patients with non-operative treatment.