To explore the effect of rehabilitation training based on the information-motivation-behavior skills (IMB) model in stroke patients. Methods: A total of 215 stroke patients were recruited and randomly divided into the study group (n=108) and control group (n=107). The control group received conventional rehabilitation training, and the study group received rehabilitation training based on the IMB model. The pre- and post-treatment motor function (FMA score), cognitive function (MoCA score), living ability (Barthel index), and quality of life (SWAL-QOL score) and the post-treatment efficacy and training satisfaction of the two groups were compared. Results: Efficacy was higher in the study group than in the control group (92.6% v.s. 66.4%, χ 2 = 6.425, P=0.011). In both groups, the FMA, MoCA, BI, and SWAL-QOL scores after treatment were increased compared to before treatment (P<0.01), and the FMA, MoCA, BI, SWAL-QOL scores in the study group were significantly greater than those in the control group (P<0.01). Training satisfaction was greater in the study group than in the control group (90.74% v.s. 78.50%, χ2 =6.194, P=0.013). Conclusion: Rehabilitation training based on the IMB model can improve the efficacy of treatment in stroke patients.