This study involves an analysis investigating the association of receiving acupuncture with long-term clinical outcomes of patients with post-stroke dysphagia. Methods: From June, 2020 to October, 2021, recruited patients from Xuanwu Hospital Capital Medical University and Beijing Hospital of Traditional Chinese Medicine who met the inclusion criteria. The patients in acupuncture group received acupuncture treatment, and the patients who did not receive acupuncture treatment in the same period were selected as the control group. The general information of patients was extracted, and the time required for the recovery of swallowing function and related clinical data were obtained through 6 months follow-up. The main outcome index is defined as the time required for clinical improvement of swallowing function (FILS score increased by 3 points). Cox risk model was established to evaluate the relationship between acupuncture treatment and swallowing function recovery. Results: During the study period, a total of 375 patients were included, and 129 patients in each group were enrolled after being treated by propensity score matching method. It took 97 days (95%CI 93-124) for patients in acupuncture group and 119 days (95%CI 108-145) for patients in control group to achieve clinical improvement, and there was a statistical difference between the two groups (HR=1.48; 95% CI 1.14-1.92; P< 0.05). 118 patients in acupuncture treatment group achieved clinical improvement (91.47%), while 107 patients (82.95% ) in control group achieved clinical improvement (RR=1.10; 95% CI 1.05-1.22; P<0.05). At 6 months, 78 patients (60.5% ) in the acupuncture treatment group achieved functional independence, while 61 patients (47.3%) in the control group (RR=1.279; 95%CI 1.019-1.616; P<0.05). 106 patients (82.2%) in the acupuncture treatment group had good function, and 91 patients (70.5% ) in the control group (RR=1.165; 95% CI 1.017-1.346; P<0.05). In the acupuncture group, the clinical improvement time of patients with acupuncture treatment time longer than one month was 87.5 days (95%CI 84-95), and the treatment time less than one month was 109 days (95%CI 94-123), the difference was statistically significant (P<0.05). There is still a difference in the recovery time of swallowing function between the two groups after the variable-adjusted Cox regression model is included (HR=1.79, 95% CI 1.34-2.39). The most common adverse event in acupuncture group was pain (36 cases, 27.9%). There was no significant difference in the incidence of adverse events related to basic treatment, pulmonary infection and stroke recurrence between the two groups (P>0.05). Conclusion: Acupuncture can promote the recovery of swallowing function in stroke patients with dysphagia; it can reduce the degree of disability and improve the long-term quality of life.