To explore the depressive-like and anxiety-like behavior of mice at different ages before and after modeling. Methods: A total of 54 C57BL/6J mice were divided into the normal control (NC) group and chronic restraint stress (CRS) group, and each group was divided into 3 subgroups according to age, including young subgroup, middle-aged subgroup, and old subgroup, for a total of 6 subgroups with 9 mice in each. The behavioral changes of mice in each group were studied through assessing the body weight, tail suspension test, forced swimming test, sugar preference test, and open field test to evaluate the depressive-like and anxiety-like behavior of the mice. Results: Within the NC group, compared with that of the young subgroup, the frequency of rearing behavior of the middle-aged subgroup was significantly decreased (P<0.05); the body weight of the old subgroup was significantly increased (P<0.05), the immobility time during tail suspension and forced swimming was significantly decreased (P<0.05), and the total distance traveled and frequency of rearing behavior in the open field were significantly decreased (P<0.05). Compared with that of the NC group, body weight of all subgroups in the CRS group was significantly decreased (P<0.05); immobility time during tail suspension and forced swimming was significantly increased (P<0.05); and sugar preference rate and the total distance traveled and frequency of rearing behavior in the open field were significantly decreased (P< 0.05). Within the CRS group, compared to that of the young subgroup, the immobility time during tail suspension and forced swimming in the old subgroup was significantly increased (P<0.05); the sugar preference rate was significantly decreased (P<0.05); and the frequency of rearing behavior in the open field was significantly decreased (P<0.05). Conclusion: With normal aging, the younger the mice, the more likely they were to show behaviors of despair; the older the mice, the more severe were their behaviors of anxiety. With stress-related aging, the older the mice, the more serious was their depressive-like and anxiety-like behavior, especially that of anhedonia caused by impairment of the reward function.