To explore the clinical effect of intensive swallowing training on patients with obstructive sleep apnea (OSA) combined with dysphagia after stroke. Methods: A total of 60 patients with OSA and dysphagia after stroke were included and randomly divided into the experimental group and control group with 30 patients in each. Both groups underwent conventional swallowing rehabilitation, and the experimental group additionally received intensive swallowing training, including intensive swallowing muscle training, neuromuscular electrical stimulation therapy, breathing training, and vocal training. Before treatment and after 4 weeks of treatment, the severity of OSA was evaluated by the water swallow test, functional oral intake classification (FOIS) assessment, and Rosenbek penetration aspiration scale (PAS); the apnea-hypopnea index (AHI) and mean blood oxygen saturation (MSaO2) were also measured. Results: Before treatment, there was no statistically significant difference between the two groups in FOIS score, PAS score, AHI, and MSaO2 (P>0.05). After 4 weeks of treatment, both groups showed decreased FOIS and PAS scores compared to before treatment (all P< 0.05), and the decrease was more apparent in the experimental group (all P<0.05). The AHI of the experimental group after treatment was significantly reduced and the MSaO2 was significantly increased compared to both the same group before treatment (all P<0.05). The AHI and MSaO2 of the control group showed no significant difference before and after treatment (all P>0.05). The PAS score showed a positive correlation with the AHI (r= 0.462, P<0.05) and no correlation with the MSaO2 (r=－ 0.046, P>0.05). Conclusion: Intensive swallowing training can significantly improve swallowing function and reduce OSA symptoms in stroke patients.