To explore the clinical characteristics of patients with chronic unilateral vestibulopathy (CUVP). Methods: Thirty-four patients with CUVP were admitted into this study. Details of disease history were collected. Vestibular function and bi-thermal caloric testing were performed, canal paresis (CP) was calculated, the video head impulse test (v-HIT) was completed, and the dizziness handicap inventory (DHI) score was determined. The correlation between CP value, disease course, and DHI value in CUVP patients was further analyzed. Results: CUVP patients accounted for 33.7% of patients with unilateral vestibulopathy during the same period, with an average age of (49.84±9.31) years and an average course of disease of (9.1±6.0) months, including 16 cases with left side CUVP and 18 cases with right side CUVP. Among the patients, 32.4% were complicated with hypertension, 14.8% with hyperlipidemia, 11.8% with diabetes, and 8.9% with immune abnormality; 47.1% were primary CUVP and 52.9% were secondary CUVP; 32.4% presented with chronic ischemic unilateral vestibulopathy, 13.5% with vestibular neuritis, and 6.3% with persistent postural-perceptual dizziness. The average CP value was (46.15±13.26)%, of which 35.3% was associated with vHIT abnormality. The mean DHI score was (38.9 ± 5.0). There was no correlation between CP value, disease course, and DHI value in this group of CUVP patients. Conclusion: CUVP is not clinically uncommon; diagnosis of etiology is difficult, and primary CUVP is most commonly seen. There is no significant correlation between the severity of clinical symptoms and the extent of peripheral vestibular injury and the course of disease, suggesting that peripheral vestibular function injury is not the only factor related to the chronic symptoms and that further evaluation of central compensation is needed.