To understand sleep quality of psychiatric medical staff and its influencing factors in normalized prevention and control period of COVID-19. Methods: A total of 228 psychiatric medical staff were enrolled and evaluated by the General Situation Questionnaire, Pittsburgh Sleep Quality Scale (PSQI), Depression Self-Assessment Scale (SDS), and Anxiety Self-Assessment Scale (SAS). The influencing factors were analyzed using unconditional binary logistic regression. Results: Among the 228 psychiatric medical staff, the incidence of sleep quality impairment was 40.35%, that of anxiety was 9.21%, and that of depression was 25.88%. The SDS score, SAS score, and PQSI factor scores and total scores of the subjects showed a statistically significant difference compared to the national normal model (P<0.01). Correlation analysis showed that PSQI total scores were positively related to SAS and SDS scores, gender, and education and were negatively related to marital status, family economic status, and health. Logistic regression analysis showed that female gender (OR=2.532, 95%CI: 1.226~5.227), anxiety (OR=3.753, 95%CI: 1.073~13.131), and depression (OR=2.290, 95%CI: 1.126~ 4.659) may be risk factors for sleep problems. Conclusion: Psychiatric medical staff may experience sleep problems during the normalized COVID-19 prevention and control periods, and this is related to gender and SAS and SDS severity.