: To analyze the changes in the brain functional network of persistent postural-perceptual dizziness (PPPD) patients using degree centrality (DC) analysis. Methods: Total 12 PPPD patients and 12 healthy subjects were enrolled for this study and were performed resting-state fMRI scans. The fMRI data were analyzed using a voxel-based DC method, and the differences between PPPD patients and healthy subjects were compared. Further correlation analysis was conducted to investigate the correlation between the DC changes and clinical features in PPPD patients. Results: Compared with that of healthy subjects, the DC value in the right cuneus and precuneus of PPPD patients was significantly lower (X=12, Y=－84, Z=21, k=126, P=0.011, FWE corrected). Correlation analysis revealed that the DC value was negatively correlated with DHI (r=－0.677, P= 0.016), DHI-F (r=－0.581, P=0.048), and DHI-E (r=－0.690, P=0.013) scores. Conclusion: In patients with PPPD, the network hub properties of the cuneus and precuneus are weakened, and this may be related to the patient's persistent dizziness and instability and worsening symptoms due to complex visual stimulation.