To observe the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with dexzopiclone tablets in the treatment of sleep disorders after cerebral infarction. Methods: Total 90 patients with sleep disorder after cerebral infarction were randomly divided into groups control and observation with 45 cases in each group. Both groups were treated with routine drug therapy, rehabilitation therapy, and dexzopiclone tablets, and the observation group was additionally treated with rTMS. Patients in both groups were assessed by PSQI and SRSS before treatment and 3 weeks after treatment, and polysomnography was performed and sleep parameters recorded to evaluate the efficacy at the end of treatment. The recurrence of sleep disorders 1 month after the end of treatment was followed up. Results: There was no significant difference in general condition, PSQI and SRSS score, and sleep parameters between the two groups before treatment (P> 0.05). Comparing data before treatment and after 3 weeks of treatment, PSQI and SRSS score, sleep latency, sleep time, sleep efficiency, wake-up frequency, wake-up time, S1% , S2% , S3-S4% , and REM% of the two groups showed a significant difference (P<0.01). There was a significant difference in the PSQI and SRSS score and sleep parameters between the observation group and control group (P<0.05), and the effective rate in the observation group was higher than that in the control group (P<0.05). One month after the end of treatment, the recurrence rate in the observation group was lower than that in the control group (P<0.05). Conclusion: rTMS combined with dexzopiclone tablets is more effective than dexzopiclone tablets alone in the treatment of sleep disorders after cerebral infarction.