To review the effectiveness of intra-orbital electroacupuncture (IEA) in the treatment of Miller Fisher Syndrome (MFS) ophthalmoplegia and the clinical characteristics of MFS ophthalmoplegia. Meth? ods: We reviewed the medical records of 27 MFS ophthalmoplegia patients who received IEA therapy and retrospectively analyzed the general data, infection status, maximum diplopia deviation before and after treatment, and treatment and recovery status. Results: The mean time from onset to the start of IEA treatment in patients was (31±46.23) days, and the mean time from treatment to recovery was (33.67±21.96) days. The number of patients clinically cured (no diplopia) was 24 (88.9%). After treatment, the average maximum diplopia deviation of the left and right eye was significantly decreased (P<0.01). Abducens nerve (CN VI) paralysis was seen in 100% of patients with 11.1% being unilaterally affected and 88.9% bilaterally affected. Combined CN III and VI paralysis occurred in 37.0% of patients, and isolated CN III and CN IV paralysis was not seen. Infection was seen in 70% of patients. Concomitant disease included hypertension (11.1%), hyperlipemia (7.4%), and type 2 diabetes (3.7%). Bell’s phenomenon was seen in 22.2% of patients including 4 bilateral and 2 unilateral cases. Ptosis occurred in 25.9% of patients including 5 bilateral and 2 unilateral cases. Bilateral pupil dilation was seen in 3.7% of patients. Conclusion: IEA therapy may accelerate the recovery from MFS ophthalmoplegia, and the clinical features of MFS ophthalmoplegia may aid diagnosis.