The resting state functional magnetic resonance imaging (fMRI) technique was used to study the patients with bipolar mania, which provides a research basis for the pathophysiological mechanism of bipolar mania. Methods: Resting fMRI data from 19 bipolar mania patients and 22 healthy controls were analyzed by using Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF)，and Pearson correlation analysis was performed between the differences in brain regions ReHo and ALFF, age, total course of disease, years of education, and BRMS score. Results: Compared with the normal control group, patients with bipolar mania had decreased ReHo in the right medial frontal gyrus and right angular gyrus. ALFF was elevated in the left precuneus and bilateral caudate nucleus. In patients with bipolar mania, there was a significant negative correlation between the right median frontal gyrus ReHo value and age (P=0.0143, r=－0.5520), while there was no significant correlation between other brain regions and age, total course of disease, years of education and BRMS score. Conclusion: Patients with bipolar mania have functional abnormalities in the right middle frontal gyrus, right angular gyrus, left precuneus and bilateral caudate nucleus.