To evaluate the effectiveness of drug-induced hypnosis for clinical emergency care in patients with dissociation disorder (DD). Methods: According to the willingness of patients to accept type of treatment, patients were divided into 3 groups, including group A (no intervention), group B (medicine), and group C (drug-induced hypnosis). The therapeutic effect (TE), Dissociative Experience Scale (DES), and adverse reactions were evaluated, and patients were followed up for 3 months. Results: A total of 83 patients completed the study. TE and DES yielded similar results. For different time points, compared with group A, the differences were significant only for group C at the 2nd week of treatment (P<0.05); at other time points, group B and group C both showed significant difference (P<0.05). Within each group, compared with the 12th week, group B showed significant difference at the 2nd and 4th week (P<0.05). The rates of adverse reactions in group C were lower than those in group B (P<0.05). Conclusion: The effect of DD treatment by medicine increases relatively slow, and there are more adverse reactions. Hypnosis therapy is just the opposite.