To study the risk factors of intracranial artery stenosis (ICAS) burden in patients with cerebral infarction. Methods: A total of 280 patients with cerebral infarction and ICAS were included in the study. The number of ICAS and the degree of stenosis in each branch were confirmed by head 320 CTA or MRA. All patients were divided into the single artery stenosis group (n=102) or multiple artery stenosis group (n=178) according to the number of artery stenosis. Intracranial artery stenosis score was used to evaluate the degree of stenosis, and according to this score, all patients were divided into the low score stenosis group (n=126) or high score stenosis group (n=154). The risk factors for stenosis were analyzed. Results: Hypertension, diabetes, hyperlipidemia, family history of stroke, and hyperhomocysteinemia were positively correlated with ICAS (P< 0.05). Hypertension, diabetes, family history of stroke, and hyperhomocysteinemia were independent risk factors for multiple artery stenosis (OR=4.900, 3.139, 1.945, 1.861) and high score stenosis (OR=4.900, 3.139, 1.945, 1.86). Conclusion: Hypertension, diabetes, family history of stroke, and hyperhomocysteinemia are independent risk factors for ICAS burden. These four risk factors can increase the number and degree of ICAS.