To investigate the effect of intermittent oral esophageal feeding (IOE) on stigma of patients with dysphagia after stroke. Methods: Eighty patients with dysphagia after stroke were randomly divided into IOE group (n=40) and NGT (nasogastric tube) group (n=40). Short form 36 health survey questionnaire (SF-36), self-rating depression scale (SDS) and stigma scale for chronic illness (SSCI) were used to assess all the cases before and after treatment. Results: After 4 weeks of treatment, SF-36 scores of two groups were higher than those before (P<0.05) and scores of IOE group were higher than those of NGT group (P< 0.05). After 4 weeks of treatment, SDS scores of two groups were lower than those before (P<0.05) and scores of IOE group were lower than those of NGT group (P<0.05). After 4 weeks of treatment, the total scores of stigma, scores of internal stigma and external stigma in the SSCI scale of two groups were lower than those before (P< 0.05) and these scores of IOE group were lower than those of NGT group (P<0.05). Conclusion: Compared with NGT, IOE could more effectively improve the quality of life in patients with dysphagia after stroke and reduce their depression and stigma.