To analyze the factors for predicting postoperative rebleeding in patients with intracerebral hemorrhage (ICH) after minimally invasive stereotactic surgery. Methods: A total of 295 ICH patients who underwent minimally invasive stereotactic surgery within 72 hours of symptom onset were included in the present study. Patients were divided into the rebleeding group (n=68) and non-rebleeding group (n=227) according to the presence or absence of postoperative rebleeding. With rebleeding and non-rebleeding as dependent variables and initial cranial CT values upon hospitalization, irregular hematoma, and history of hypertension as independent variables, we used binary Logistic regression to assess the relationship between the presence of postoperative rebleeding and the shape of initial hematoma and hypertension history. Results: There were 47 patients (69.1%) with irregular hematoma in the rebleeding group while only 69 patients (30.39%) in the non-rebleeding group. The NIHSS score at discharge of the rebleeding group was significantly higher than that of the non-rebleeding group. Upon extubation, the rebleeding group displayed greater residual hematoma volume than the non-rebleeding group. Binary Logistic regression showed that irregular hematoma, initial CT values, and hypertension history were independent predictors of postoperative rebleeding. Conclusion: CT value at hospitalization, irregular hematoma, and history of hypertension are predictive factors for postoperative rebleeding in patients who underwent minimally invasive stereotactic surgery for the treatment of ICH.