To investigate the correlation between patent foramen ovale (PFO) and migraine using meta-analysis. Methods: The databases of PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, VIP, WanFang Data, and CBM databases were searched to collect case-control studies, cross-sectional studies, or cohort studies that investigated the association between patent foramen ovale and migraine headaches. The retrieval time span was from inception to August 1, 2018. Studies were screened according to inclusion and exclusion criteria, data were extracted, and quality was evaluated by the NOS by 2 reviewers independently. Meta-analysis was conducted using RevMan 5.3 software. Results: A total of 30 articles were included. The sample size was 9177 cases. Meta-analysis showed that there was a statistically significant difference in the incidence of PFO between the migraine group and the healthy control group [OR=3.19, 95% CI (2.20~4.63), P<0.01]. There was statistically significant difference in the incidence of PFO between the migraine with aura group and the healthy control group [OR=3.71, 95%CI (2.13~6.46), P<0.01]. The incidence of PFO in the migraine without aura group was higher than that in the control group [OR=1.48, 95% CI(1.09~2.00), P=0.01]. The incidence of PFO in the migraine with aura group was higher than that in the migraine without aura group [OR=2.32, 95% CI (1.96~ 2.76), P<0.01]. The PFO group had a higher incidence of migraine headaches compared to the healthy control group [OR=2.58, 95% CI (1.57~4.25), P<0.01]. Conclusion: There is a clear correlation between PFO and migraine.