To discuss the effect of Pramipexole combined with progressive resistance training on improving muscular tension in patients with Parkinson’s disease. Methods: Total 125 patients with Parkinson’s disease were enrolled and were randomly divided into groups control (n=45), anti-resistance training (n=40) and Parkinson’s exercise (n=40). All the groups were treated with Pramipexole. The anti-resistance training group and the Parkinson’s exercise group were also given resistance training and Parkinson’s exercise rehabilitation, respectively.The Parkinson’s Rating Scale (UPDRS), the Parkinson’s Disease Webster Scale and the Berg Balance Scale were used to evaluate at different time points. The modified Ashworth scale was used to evaluate the change in muscular tension. Results: Among the 3 groups, the UPDRS scores were the highest in the anti-resistance training group (P<0.05), and the UPDRS scores in the anti-resistance training and the Parkinson’s group were gradually increased during the follow-up period (P<0.05). Among the four time points, the Berg balance scale score and Webster symptom score of the three groups were the highest at the time of enrollment, and the lowest at the 18 months follow-up (P<0.05). The scores of 3 months, 12 months and 18 months of follow-up were all different with statistical significance, and the anti-resistance training group had the lowest score (P< 0.05). There was 1 case of sleepiness and 1 case of nausea in the anti-resistance training group and the control group, respectively. There were significant differences in the Ashworth scale scores between the 3 groups at 4 time points, and the scores were the highest at the time of enrollment and the lowest at the 18 months follow-up (P<0.05). The Ashworth scale scores of the follow-up 3 months, 12 months, and 18 months were statistically significant, with the lowest scores in the anti-resistance training group and the highest in the control group (P<0.05). Conclusion: The effect of Pramipexole combined with progressive resistance training on improving muscular tension in patients with Parkinson’s disease is better than that of Pramipexole combined with Parkinson’s exercise and Pramipexole alone