To explore the effect of group mindfulness-based cognitive therapy (MBCT) on patients with panic disorder (PD). Methods: A total of 120 patients with panic disorder were enrolled. The patients were randomly divided into the study group (60 cases, 56 cases completed) and control group (60 cases, 53 cases completed). Both groups received medication, and the study group also simultaneously received group MBCT. The two groups were evaluated before treatment and 12 weeks and 6 months after intervention using the Panic Disorder Severity Scale (PDSS), State-Trait Anxiety Inventory (STAI-Form Y), Five Facet Mindfulness Questionnaire (FFMQ), and Mental Tracking Paradigm for heartbeat perception. Results: The difference in PDSS score, S-AI factor of the STAI-Form Y, acting with awareness and non-judge facets of the FFMQ, and level of heartbeat perception was statistically significant in the inter-group effect, time effect, and group × time interactions (P<0.05). The difference in T-AI factor in the STAI-Form Y and the observation, description, and non-response factors in the FFMQ was statistically significant in the inter-group effect and time effect (P<0.05). Conclusion: Group mindfulness-based cognitive therapy can effectively alleviate anxiety symptoms, improve mindfulness, and reduce heartbeat perception in PD patients.