Clinical Features of Subjective Cognitive Decline in Patients with Parkinson’s Disease

Neural Injury and Functional Reconstruction ›› 2019, Vol. 14 ›› Issue (1) : 19-21.

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Neural Injury and Functional Reconstruction ›› 2019, Vol. 14 ›› Issue (1) : 19-21.
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Clinical Features of Subjective Cognitive Decline in Patients with Parkinson’s Disease

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Abstract

To study clinical characteristics and related factors of subjective cognitive decline (SCD) in patients with Parkinson's disease (PD). Methods: Depending on the presence of SCD, 82 patients with PD were divided into two groups, the PD-SCD+ group (n=42) and the PD-SCD - group (n=40), to assess cognitive dysfunction (including attention, executive function, language function, memory function, visual space function, etc.) and study the clinical characteristics of SCD in PD patients and the relationship between SCD and age, duration, Hoehn-Yahr grade, and UPDRS score. Results: There was significant difference between PD-SCD+ and PD-SCD - patients in memory (immediate and delayed memory), attention (digital span test and reverse digital test), and executive function (line test) (t=5.578, P<0.001; t=2.511, P<0.05; t=2.801, P<0.05). Bivariate correlation analysis showed that SCD in the PD-SCD+ group was negatively related with the severity of disease condition (H-Y classification), duration, and UPDRS (Part I) score (r=-0.391,P=0.020;r=-0.383,P=0.025;r= -0.528,P=0.001). No significant difference was observed between PD-SCD+ and PD-SCD- patients in age and UPDRS (Parts Ⅱ and Ⅲ) score (r=-0.132,P=0.451;r=0.487,P=0.156;r=-0.443,P=0.124). Conclusion: The patients with PD-SCD had abnormal immediate and delayed memory, and SCD was corelated with course of disease, disease severity, and UPDRS Part I score.

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Parkinson's disease

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Clinical Features of Subjective Cognitive Decline in Patients with Parkinson’s Disease[J]. Neural Injury and Functional Reconstruction. 2019, 14(1): 19-21
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