To prepare an effective and biodegradable tissue engineering scaffold with controlled release for Chondroitinase ABC (ChABC) and cyclic adenosine monophosphate(cAMP) which can release drug slowly and steadily with low nerve stimulation and promote central nerve system recovery and regeneration. Methods: ChABC-and cAMP-loaded polypropylene carbonate (PPC) and chitosan (CS) scaffold for tissue engineering was prepared by electrospinning. Analysis was performed on scaffold diameter, drug load, and encapsulation efficiency. Drug release rate and drug inactivation ratewas observed with phosphate buffer solution medium, and scaffold degradation rate was assessed. Results：ChABC and cAMP slow-release tissue engineering scaffolds in PPC possessed a mass concentration of 8% and voltage of 10~15 kV. At a length of 15~ 20 cm, it could be spun to a diameter of approximately 3 μm. The pure PPC fiber was smooth and displayed a uniform diameter. The chitosan microsphere was smooth. The scaffold spun with a PPC and chitosan blend showed a beaded structure and could slowly release active ChABC and cAMP; 12 days after construction, the scaffold showed a mass degradation rate of approximately 7%. Conclusions：Electrospinning method has been successfully applied to prepare PPC and CS tissue engineering scaffolds containing ChABC and cAMP; its advantages include stable drug release, local application without nerve stimulation, and biodegradability