To investigate the characteristics of plantar pressure distribution and gait in patients with Parkinson's disease (PD) and the therapeutic effect of targeted rehabilitation training. Methods: Fifty patients with primary PD were included in this study as the PD group, and 50 healthy middle-aged and elderly subjects were selected as the control group. Static and dynamic plantar pressure of subjects in both groups was measured using the Gaitview system. Results: During static assessments, the left and right foot Zone 5 (the fifth metatarsal) plantar pressure was (40.41 ± 22.46) kPa and (30.42 ± 13.14) kPa respectively in the PD group, significantly higher than the (21.60 ± 10.39) kPa and (20.79 ± 9.10) kPa in the control group (both P<0.001). During dynamic assessments, the two groups showed no significant difference in plantar pressure in all zones of the foot (P>0.05). The left and right foot heel-strike duration of the PD group was (0.84±2.05) s and (1.64±3.17) respectively, both being significantly shorter than the (4.72±2.96) s and (6.33±6.27) s of the control group (both P<0.001). Conclusion: Plantar pressure information is essential for the analysis of the characteristics and extent of gait disorders in patients with PD. Targeted rehabilitation training should emphasize heel-first landing.