To investigate the symptoms of post-traumatic stress disorder (PTSD), anxiety, and depression, as well assleep quality status in military personnel stationed in Xinjiang. Methods: Four hundred military personnelstationed in Xinjiang were investigated through structural questionnaire survey and psychological scale evaluation. The diagnosis of PTSD was first determined withthe PTSD screening scale (PCL-C) then assessedby psychiatrists according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for diagnosis of PTSD; one-on-one psychiatrist evaluation of patients whose PCL-C score indicate PTSD confirmed the diagnosis. The symptoms of comorbidity were assessed by the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Athens Insomnia Scale (AIS) for sleep quality status,and psychological stress questionnaire. The data were analyzed by SPSS17.0 software. Results: Of the 356 valid questionnaires received, 27 cases (7.58% ) were confirmedwithPTSD. The PTSD group and non-PTSD group showed no statistical difference with respect tolength of service,education level, marital status, training injury history, ethnicity, essential personnel status, or position of post. Participation in entertainment and management status is associated with a significantly increased rate of PTSD diagnosis. There was significant difference in the two-week stress and insomnia status between the PTSD group and non-PTSD group (P<0.001); the PTSD group showed significantly higher levels of anxiety and depression.Conclusion: Due to Xinjiang’s regional uniqueness, its military personnel experience greater psychological stress and show a higher prevalence of PTSD than the general population