目的：探究亲环素A（cyclophilin A，CyPA）促糖尿病大鼠动脉粥样硬化进展的机制。 方法：雄性Wistar大鼠30只随机分3组造模：对照组、动脉粥样硬化组（AS组）、糖尿病动脉硬化组（DM组），各10只。16 周后检测三组大鼠血糖、动脉硬化指标及炎性因子；采用HE染色观察大鼠腹主动脉病变；采用蛋白质印 迹、免疫组织化学检测各组大鼠动脉CyPA、p-ERK1/2及NF-κB的表达。结果：随造模时间延长DM组大鼠 体重下降，血糖升高，血清炎性因子增加，动脉硬化指数显著增高，差异均有统计学意义（均P＜0.05）。DM 组大鼠血管壁CyPA、p-ERK1/2和NF-κB蛋白表达显著增加，差异有统计学意义（均P＜0.05）。结论：CyPA 蛋白在糖尿病大鼠病变血管壁中显著表达，可能参与糖尿病动脉血管粥样硬化形成和发展。

To investigate the mechanism by which cyclophilin A (CyPA) promotes the progression of atherosclerosis in diabetic rats. Methods: Thirty male Wistar rats were randomly divided into three groups (n=10 each): the control group, the atherosclerosis group (AS group), and the diabetic atherosclerosis group (DM group). After 16 weeks, blood glucose levels, atherosclerotic indices, and inflammatory cytokines were measured in all three groups. Pathological changes in the abdominal aorta were observed using hematoxylin-eosin (HE) staining. The expression of CyPA, phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), and nuclear factor-kappa B (NF-κB) in the arteries of each group was detected by Western blotting and immunohistochemistry. Results: Over time, the DM group exhibited significant weight loss, elevated blood glucose levels, increased serum inflammatory cytokines, and a markedly higher atherosclerotic index compared to the other groups (all P<0.05). The protein expression of CyPA, p-ERK1/2, and NF-κB in the vascular walls of the DM group was significantly increased (all P<0.05). Conclusion: CyPA protein is highly expressed in the vascular walls of diabetic rats with atherosclerotic lesions, suggesting its potential involvement in the formation and progression of diabetic vascular atherosclerosis.