缺血性脑卒中具有高发病率、高致残率的特点。最新研究表明肠道菌群代谢产物氧化三甲胺（trimethylamine-N-oxide，TMAO）可促进动脉粥样硬化的发生、发展，提高血小板的反应性，增加血栓形成的风 险。本文对TMAO在缺血性脑卒中的研究进展进行综述。

Ischemic stroke is characterized by high morbidity and disability rates. Recent studies have revealed that trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, promotes the initiation and progression of atherosclerosis, enhances platelet reactivity, and increases thrombotic risk. This review summarizes the current research progress on the role of TMAO in ischemic stroke.