脊髓损伤（spinal cord injury，SCI）是一种严重的外伤性疾病，对社会、家庭及患者均造成巨大影响。 SCI后，神经轴突难以自发性再生修复，且临床尚缺乏有效的治疗方法。既往研究显示在SCI后，多种生长 因子具有保护神经组织、刺激轴突再生与髓鞘化、减少瘢痕形成等重要作用。水凝胶是目前较为理想的材 料支架，可保护生长因子不被降解，实现生长因子原位给药与持续性释放，在SCI早期及随后的组织再生修 复阶段均起到重要作用。本文重点回顾及综述在脊髓继发性损伤与组织再生的不同阶段，运用水凝胶搭载 生长因子治疗SCI的研究进展。

Spinal cord injury (SCI) is a severe traumatic disease that has a profound impact on society, families, and patients. After SCI, neuronal axons exhibit limited spontaneous regenerative capacity, and effective clinical treatments remain lacking. Previous studies have demonstrated that various growth factors play crucial roles in protecting neural tissue, stimulating axonal regeneration and remyelination, and reducing scar formation after SCI. Hydrogels are currently considered ideal biomaterial scaffolds, as they can protect growth factors from degradation, enable localized delivery and sustained release of growth factors, and play significant roles in both the early phase and subsequent tissue regeneration stages after SCI. This article focuses on reviewing the research progress on hydrogel-delivered growth factor therapies for SCI during different stages of secondary damage and tissue regeneration.