目的：探讨缺血性脑卒中急性期抑郁状态与1年后认知及生活功能的相关性。方法：收集2018年6月 至2019年6月在武汉市中心医院及同济医院住院的急性缺血性脑卒中（acute ischemic stroke，AIS）患者的 临床资料。出院时，采用流调中心抑郁自评量表（Center for Epidemiological Studies Depression Scale， CES-D）评估卒中后抑郁状态（post stroke depression symptoms，PSDS）的程度。随访1年，采用简易精神状 态量表（Mini-Mental State Examination，MMSE）评估认知功能，采用改良的 Rankin 量表（modified Rankin Scale，mRS）评估生活功能。运用多因素Logistic回归分析PSDS与卒中1年后功能预后的相关性。结果： 共纳入 219 例 AIS 患者，根据卒中急性期是否有抑郁状态分为 PSDS 组和非 PSDS 组。基线数据分析显 示，PSDS组的BMI及卒中类型与非PSDS组相比差异有统计学意义（P＜0.05）。多因素Logistic回归分析 结果显示，与非PSDS组相比，PSDS组在卒中1年后认知障碍患者的比例更低（P＜0.001），在mRS良好预后 的比例上，2组之间差异无统计学意义。结论：缺血性脑卒中急性期抑郁状态与卒中1年后发生认知障碍的 风险升高显著相关，与良好生活功能预后无相关性。

To investigate the correlation between depressive state during the acute phase of ischemic stroke and cognitive/functional outcomes one year later. Methods: Clinical data were collected from patients with acute ischemic stroke (AIS) admitted to Wuhan Central Hospital and Tongji Hospital from June 2018 to June 2019. At discharge, the severity of post-stroke depressive state was assessed using the Center for Epidemiological Studies Depression Scale (CES-D). During a one-year follow-up, cognitive function was evaluated using the Mini-Mental State Examination (MMSE), and functional outcome was assessed using the modified Rankin Scale (mRS). Multivariate logistic regression analysis was performed to examine the correlation between post-stroke depressive state (PSDS) and functional prognosis one year after stroke. Results: A total of 219 AIS patients were included and divided into PSDS and non-PSDS groups based on the presence of depressive state during the acute stroke phase. Baseline data analysis revealed significant differences in BMI and stroke type between the PSDS and non-PSDS groups (P<0.05). Multivariate logistic regression analysis indicated that compared to the non-PSDS group, the PSDS group had a significantly lower proportion of patients with cognitive impairment one year after stroke (P<0.001), while no statistically significant difference was observed between the two groups in the proportion of patients with good mRS prognosis. Conclusion: Depressive state during the acute phase of ischemic stroke is significantly associated with an increased risk of cognitive impairment one year after stroke but is not correlated with favorable functional outcome.