神经退行性疾病的病理特征主要包括异常错误折叠蛋白质或多肽的积聚和沉积。自噬可以清除细胞 内聚集蛋白和功能失调的细胞器，是延缓神经退行性疾病的重要靶点。自噬体产生或其成熟过程受损都会 促进神经退行性疾病发生发展。深入了解调节细胞自噬的信号转导途径对于制定相关疾病的治疗策略至 关重要。本文主要介绍自噬在神经退行性疾病中的重要作用及其相关分子机制。

The pathological features of neurodegenerative diseases mainly include the accumulation and deposition of abnormally misfolded proteins or peptides. Autophagy can clear intracellular aggregated proteins and dysfunctional organelles, making it an important target for delaying the progression of neurodegenerative diseases. Impairments in the production or maturation process of autophagosomes can promote the development and progression of neurodegenerative diseases. A thorough understanding of the signal transduction pathways regulating autophagy is crucial for devising treatment strategies for related diseases. This paper mainly introduces the important role of autophagy in neurodegenerative diseases and its associated molecular mechanisms.