目的：系统评价帕金森病（Parkinson’s disease，PD）震颤严重程度与3种单胺类神经递质（多巴胺、血 清素、去甲肾上腺素）的相关性。方法：检索PD震颤与3种单胺类神经递质相关性分析的研究，进行Meta 分析。结果：共纳入26篇文献，包括1878例研究对象。Meta分析结果显示，对侧壳核多巴胺功能与PD震 颤不相关[r=－0.05, 95%CI(－0.13, 0.03)，P=0.194]。亚组分析显示，在疾病早期（病程≤5年）同侧尾状核多 巴胺功能与PD震颤正相关[r=0.17, 95%CI(0.10, 0.25), P＜0.001]。中缝核血清素能与PD震颤的相关性分析 结果不稳定[随机效应模型：r=－0.23, 95%CI(－0.44, 0.02), P=0.067；固定效应模型：r=－0.14, 95%CI(－0.23, －0.04), P=0.004]。去甲肾上腺素能与PD震颤相关性的研究所用的示踪剂差别较大，本研究进行了系统综 述。结论：PD震颤与多巴胺能的关系可能受脑区及病程的影响，在疾病早期同侧尾状核多巴胺功能与PD 震颤严重程度正相关。PD震颤与血清素能及去甲肾上腺素能的关系有待进一步研究，使用一致的、特异性 的示踪剂至关重要。

To systematically evaluate the correlation between tremor severity and three monoaminergic neurotransmitters (dopamine, serotonin, and norepinephrine) in Parkinson’s disease (PD). Methods: Studies analyzing the correlation between PD tremor and these three monoaminergic neurotransmitters were searched, and a meta-analysis was conducted. Results: A total of 26 studies were included, involving 1878 participants. The meta-analysis revealed no correlation between contralateral putamen dopamine function and PD tremor [r=－0.05, 95%CI (－0.13, 0.03), P=0.194]. Subgroup analysis demonstrated a positive correlation between ipsilateral caudate dopamine function and PD tremor in the early stage of the disease (disease duration≤5 years) [r=0.17, 95%CI (0.10, 0.25), P<0.001]. The results of the correlation analysis between raphe nuclei serotonergic function and PD tremor were unstable [random-effects model: r=－0.23, 95% CI (－0.44, 0.02), P=0.067; fixed-effects model: r=－0.14, 95%CI (－0.23, －0.04), P=0.004]. The tracers used in studies investigating the correlation between noradrenergic function and PD tremor varied significantly, so a systematic review was conducted for this part. Conclusion: The relationship between PD tremor and dopaminergic function may be influenced by brain region and disease duration. In the early stage of the disease, ipsilateral caudate dopamine function is positively correlated with PD tremor severity. The relationships between PD tremor and both serotonergic and noradrenergic functions require further investigation, and it is crucial to use consistent and specific tracers.