目的：应用眼震视图（video-oculography，VOG）检查对进行性核上性麻痹（progressive supranuclear palsy，PSP）和帕金森病（Parkinson’s disease，PD）患者的视眼动及前庭眼动通路进行定量分析，明确PSP和 PD的眼动障碍特征，并筛选具有鉴别诊断价值的指标。方法：回顾性纳入PSP患者24例和PD患者48例的 VOG检查数据，包括自发性眼震、凝视、扫视、摇头试验和前庭眼反射抑制（vestibulo-ocular reflex suppression，VORS）试验。结果：PSP患者中，垂直凝视范围受限、垂直扫视峰速度减慢、扫视欠冲及潜伏期延长、 水平凝视诱发性眼震、水平扫视欠冲和扫视速度减慢以及 VORS功能异常的发生率均显著高于PD患者（均 P＜0.05）。PD患者中自发眼震的发生率显著高于PSP患者（P=0.006）。扫视侵扰、垂直扫视欠冲、水平扫视 潜伏期延长、倒错性摇头性眼震的发生率在PSP与PD组间差异无统计学意义（均P＞0.05）。结论：视眼动 和前庭眼动检查在鉴别 PSP与PD方面具有重要临床价值。其中，垂直扫视功能障碍和VORS功能异常可 作为区分PSP和PD的关键性鉴别诊断指标。

To quantitatively characterize the visuo-oculomotor and vestibulo-oculomotor pathways in progressive supranuclear palsy (PSP) and Parkinson's disease (PD) using video-oculography (VOG), delineate the profile of oculomotor dysfunction in each disorder, and identify parameters with differential diagnostic value. Methods: We retrospectively analyzed vestibulo-ocular reflex suppression (VOG) data from 24 PSP patients and 48 PD patients. The data included measurements of spontaneous nystagmus, gaze holding, saccades, head-shaking test, and the vestibulo-ocular reflex suppression (VORS) test. Results: In PSP patients, the incidence of restricted vertical gaze range, decreased vertical saccadic peak velocity, saccadic hypometria and prolonged latency, horizontal gaze-evoked nystagmus (GEN), horizontal saccade hypometria and reduced velocity, as well as VORS functional abnormalities, were all significantly higher than those in PD patients (P< 0.05 for all). Spontaneous nystagmus was significantly more prevalent in PD patients than that in PSP patients (P= 0.006). The incidence of saccadic intrusions, vertical saccade hypometria, prolonged horizontal saccade latency, and perverted head-shaking nystagmus (pHSN) showed no significant difference between the PSP and PD groups (P>0.05 for all). Conclusion: Oculomotor and vestibulo-ocular assessments holds significant clinical value in differentiating PSP from PD. Specifically, vertical saccade dysfunction and VORS abnormalities serve as critical differential diagnosis indicators for distinguishing between the two conditions.