目的：调查视神经脊髓炎谱系疾病（neuromyelitis optica spectrum disorder，NMOSD）患者恐惧疾病进 展现状并分析其影响因素。方法：选择2024年6月～2025年3月武汉市某三甲医院神经内科门诊及住院的 NMOSD患者120例作为调查对象，采用一般资料调查表、恐惧疾病进展简化量表（FoP-Q-SF）、医学应对方 式问卷（MCMQ）对入组患者进行调查和统计分析。结果：NMOSD患者恐惧疾病进展得分为（36.57±7.72） 分，其中48例（40%）为中度恐惧，66例（55%）为重度恐惧；回避应对、屈服应对以及是否有顽固性呃逆、恶 心、呕吐症状，是其主要影响因素（均P＜0.05）；回避应对与恐惧疾病进展成正相关（P＜0.01），屈服应对与 恐惧疾病进展成负相关（P＜0.01）。结论：NMOSD患者恐惧疾病进展程度较高。临床干预应重点关注引导 患者减少回避应对，关注其屈服应对反应所揭示的心理需求；同时，积极管理顽固性呃逆、恶心、呕吐等躯体 症状，以有效缓解患者的恐惧心理。

To investigate the current status of fear of disease progression (FoP) in patients with neuromyelitis optica spectrum disorder (NMOSD) and analyze its influencing factors. Methods: A total of 120 patients with NMOSD from the neurology outpatient and inpatient departments of a tertiary hospital in Wuhan were selected as participants between June 2024 and March 2025. The enrolled patients were assessed using the General Information Questionnaire, Fear of Progression Questionnaire-Short Form (FoP-Q-SF), and Medical Coping Modes Questionnaire (MCMQ), followed by statistical analysis. Results: The mean Fear of Disease Progression (FoDP) score among NMOSD patients was 36.57 ± 7.72. Of the participants, 48(40% ) exhibited moderate fear, and 66(55% ) demonstrated severe fear. Key influencing factors included avoidant coping, yielding coping, and the presence of refractory hiccups, nausea, or vomiting symptoms (all P<0.05). Avoidant coping showed a positive correlation with FoDP (P<0.01), while yielding coping negatively correlated with FoDP (P<0.01). Conclusion: Patients with NMOSD experience a high level of fear regarding disease progression. Clinical interventions should prioritize guiding patients to reduce avoidant coping strategies while addressing the psychological needs revealed by their yielding coping responses. Additionally, proactive management of refractory hiccups, nausea, and vomiting is essential to alleviate patients’fears effectively.