目的：本研究使用功能性近红外光谱成像（functional near-infrared spectroscopy，fNIRS）分析卒中后 亚急性期命名性失语患者的静息状态和图片命名过程中的皮质激活模式。方法：研究选择15例卒中后亚 急性期命名性失语患者纳入失语组，同时招募20名年龄和性别匹配的健康受试者纳入对照组。在静息态 和图片命名任务中收集2组受试者的fNIRS数据，并选择相关语言脑区分析大脑激活情况。结果：在静息 状态下，与对照组相比，失语组的左侧缘上回和右侧颞上回的氧合血红蛋白浓度降低（P＜0.05），并且在左 侧缘上回-右侧Broca区和左侧缘上回-右侧颞中回的功能连接增强（P＜0.05）。在图片命名任务期间，与 对照组相比，失语组在左侧辅助运动区、左侧角回以及左侧和右侧缘上回脑区的激活降低（P＜0.05）。此 外，图片命名期间左侧缘上回脑区的β值与图片命名任务的得分呈显著正相关（P＜0.05）。结论：本研究通 过fNIRS检测发现，左侧缘上回在命名性失语患者中激活显著降低，且其激活水平与图片命名任务表现正 相关，支持其在语言障碍中的关键作用及作为康复治疗靶点的潜力。

This study employed functional near-infrared spectroscopy (fNIRS) to analyze cortical activation patterns during resting state and picture naming tasks in patients with subacute post-stroke anomic aphasia. Method: Fifteen patients with subacute post-stroke anomic aphasia were enrolled as the aphasic group, and twenty age- and gender-matched healthy subjects were recruited as controls. fNIRS data were collected from both groups during resting state and picture naming tasks, with analysis focused on language-related brain regions. Results: During the resting state, the aphasic group showed reduced oxygenated hemoglobin concentrations in the left supramarginal gyrus (SMG) and right superior temporal gyrus (STG) compared to controls (P<0.05). Enhanced functional connectivity was observed between the left SMG and right Broca’s area, as well as between the left SMG and right middle temporal gyrus (MTG) (P< 0.05). During picture naming, the aphasic group exhibited decreased activation in the left supplementary motor area (SMA), left angular gyrus, and bilateral SMG compared to controls (P<0.05). Notably, the β-value of the left SMG during picture naming correlated positively with task performance scores (P<0.05). Conclusion: In this study, fNIRS revealed significantly reduced activation in the left SMG among anomic aphasic patients, with activation levels positively correlating with picture-naming performance. These findings underscore the critical role of the left SMG in language deficits and its potential as a therapeutic target for rehabilitation.