额颞叶痴呆（frontotemporal dementia，FTD）是常见的神经变性病和早发型痴呆，突出表现为精神行 为异常和认知障碍，由于发病机制不清、异质性突出，目前早期诊断和治疗困难。近年来由于技术不断成 熟，FTD体液标志物相关研究成为热点，有较多研究已经发现了一些有潜在应用价值的标志物分子。本文 特将近期相关研究归纳总结，以期临床医生能够了解FTD早期诊断标志物的研究进展，为后续的基础研究 提供参考方向，为临床应用提供可能选择。

Frontotemporal dementia (FTD) is a common neurodegenerative disorder and an early-onset form of dementia, characterized by prominent psychiatric and behavioral abnormalities and cognitive impairment. Due to its unclear pathogenesis and marked heterogeneity, early diagnosis and treatment are currently challenging. In recent years, as technology has matured, research on FTD biofluid markers has become a hot topic, with many studies identifying potential marker molecules for application. This article summarizes recent related research in order to provide clinicians with an understanding of the progress in early diagnostic markers for FTD, to offer reference directions for subsequent basic research, and to present possible options for clinical application.