快感缺失是抑郁症的核心症状之一，也是抑郁症治疗中的难点，是抑郁症患者出现病程长、生活质量 大幅下降、社会功能严重受损的重要预测因子之一。当前国内外对抑郁症快感缺失表型的研究为探索其 发生发展机制提供了重要信息，但仍未建立一个完整可靠的病因网络，这使得研发针对性的靶向治疗方案 受到局限。因此，探索抑郁症快感缺失表型的病因对临床治疗具有重要的意义。现对既往有关抑郁症快 感缺失的文献进行总结，从社会心理因素、生理生化因素、脑影像及神经环路与基因遗传等方面介绍抑郁 症快感缺失的发病机制研究进展。

Anhedonia is one of the core symptoms of depression, and it is also a difficult point in the treatment of depression. It is one of the important predictors for patients with long-term course, significant decline in quality of life and severe impairment of social function. Current research on the anhedonia phenotype of depression has provided important information for exploring the mechanism of its occurrence and development, but a complete and reliable etiological network has not yet been established, which limits the development of targeted therapy. Therefore, exploring the etiology of anhedonia phenotype in depression is of great significance for clinical treatment. This review summarizes the previous literature on anhedonia in depression, and introduces the research progress on the pathogenesis from the aspects of social psychological factors, physiological and biochemical factors, brain imaging, neural circuits and genetic inheritance.