脊髓损伤是严重的创伤性疾病，影响患者损伤部位及以下的运动、感觉与自主神经功能障碍。现有 治疗手段单一、且效果不佳。间充质干细胞源性外泌体可通过调节炎症反应、改善血-脊髓屏障、减少细胞 凋亡、促进轴突生长、修复瘢痕组织等方式，改善和治疗脊髓损伤造成的神经细胞功能障碍。因其在临床 治疗应用上的潜力，间充质干细胞源性外泌体成为治疗脊髓损伤的研究热点。

Spinal cord injury is a severe traumatic disease that affects motor、sensory and autonomic dysfunction at and below the site of injury. Current treatment options are limited and often ineffective. Mesenchymal stem cell-derived exosomes have shown promise in improving and treating nerve cell dysfunction caused by spinal cord injury through regulating the inflammatory response, improving the blood-spinal barrier, reducing cell death, promoting axon growth, and repairing scar tissue. Due to their potential in clinical application, mesenchymal stem cell-derived exosomes are a hot topic in the treatment of spinal cord injury.