阿尔茨海默病（Alzheimer’s Disease，AD）是一种以进行性认知功能下降及行为改变为临床表现的中 枢神经退行性疾病。研究表明补体系统的过度激活在AD病变过程中发挥着重要的作用，抑制补体系统 的过度激活为AD的诊疗提供了临床新方向。本文将阐述补体系统与AD疾病发展之间的相关性和研究 进展，并概述补体靶向治疗AD的进展。

Alzheimer’s Disease (AD) is a neurodegenerative disorder of the central nervous system manifested by progressive cognitive decline and behavioral alterations. Research indicates that the overactivation of the complement system significantly contributes to the pathology of AD, and suppressing this overactivation offers novel clinical approaches for AD diagnosis and treatment. This paper will discuss the relationship and advancements in research between the complement system and AD progression, as well as outline the progress in complement-targeted treatments for AD.