阿尔茨海默病（Alzheimer's disease，AD）已成为中国65岁及以上人群的第四大死因，PET/CT在AD 的临床诊断和致病机制研究中发挥了重要的作用，阿尔茨海默病神经影像学倡议（Alzheimer’s Disease Neuroimaging Initiative，ADNI）中的PET/CT联合数字技术为跟踪患者认知变化轨迹、提升临床诊断精度提 供重要的科学支撑。本文重点综述了近3年ADNI中的PET/CT在探索AD病理进展模式及早期诊断的研 究进展。

Alzheimer's disease (AD) has become the fourth leading cause of death among people aged 65 and above in China. PET/CT plays a significant role in the clinical diagnosis and research on the pathogenesis of AD. The combined use of PET/CT and digital technology within the Alzheimer's Disease Neuroimaging Initiative (ADNI) provides important scientific support for tracking the trajectory of cognitive changes in patients and improving the accuracy of clinical diagnosis. This article focuses on reviewing the research progress in exploring the pathological progression patterns and early diagnosis of AD using PET/CT within ADNI over the past three years.