脊髓损伤（spinal cord injury，SCI）是一种严重的神经系统疾病，其主要的临床治疗包括急救处理、手 术、药物治疗和康复治疗。常规的药物治疗存在难以穿越血脊髓屏障（blood-spinal cord barrier，BSCB）、不 能靶向受损的神经组织的问题。纳米递送系统具有良好的可控释放特性和靶向脊髓组织的能力，可以克 服常规给药方式的不足，通过精细化设计组装和外表修饰赋予纳米递送系统出众的治疗效果。本文综述 了在SCI中纳米粒子用于药物递送的研究进展，并着重介绍在SCI药物递送系统中的靶向策略及具有运用 前景的纳米粒子及其各自特性与局限性，以及将纳米递送技术应用于临床SCI修复领域所需克服的努力与 障碍。

Spinal cord injury (SCI) is a severe neurological condition. The primary clinical interventions include emergency treatment, surgical procedures, drug therapy, and rehabilitation programs. However, Conventional drug therapy is difficult to cross the Blood-spinal cord barrier (BSCB) and cannot target damaged nerve tissue. In contrast, nano-drug delivery systems offer controlled release properties and can precisely target spinal cord tissue, thereby overcoming the limitations of traditional drug therapies. Through exquisite design, assembly and external modification, the nanomedical drug delivery system has outstanding therapeutic effects. This paper reviews the current research status of Nanoparticles for drug delivery in SCI. Furthermore, this article emphasizes the targeting strategies utilized in drug delivery systems for spinal cord injury, as well as the potential of nanoparticles and their respective characteristics and limitations. Finally, the efforts and obstacles to be overcome in the application of nanoparticle drug delivery technology in the field of clinical SCI repair are discussed.