中枢神经系统（central nervous system，CNS）疾病由于病因和发病机制的复杂性，目前仍缺乏有效的 治疗手段。GABAB受体广泛分布于神经元和胶质细胞中，在调节神经递质释放和神经元兴奋性中发挥重 要作用。现已证明GABAB受体参与多种CNS疾病的发生发展，包括癫痫、抑郁、脑卒中、阿尔茨海默病及 自身免疫性脑炎等疾病。因此，明确GABAB受体在CNS疾病中的病理角色，对GABAB受体相关药物的开 发及临床应用至关重要。本文从GABAB受体结构和功能出发，综述其参与各类CNS疾病的具体机制。

Objective Due to the complexity of the etiology and pathogenesis, there is still no effective therapeutic strategies for diseases of the central nervous system (CNS). GABAB receptors are widely distributed in neurons and glial cells, and play important roles in the regulation of neurotransmitter release and neuronal excitability. It has been proven that GABAB receptors are involved in the development of a variety of CNS diseases, including epilepsy, depression, stroke, Alzheimer's disease, and autoimmune encephalitis. Therefore, clarifying the roles of GABAB receptors in the pathology of CNS diseases is essential for the development and clinical application of GABAB receptor-related drugs. In this paper, the specific mechanisms of GABAB receptors involved in various CNS diseases are reviewed based on the structures and functions of BABAB receptors.