阿尔茨海默病（AD）是一种中枢神经系统退行性疾病。神经炎症是影响AD进展的关键因素，研究显 示AD患者脑实质内存在外周T淋巴细胞及其亚群的浸润，提示外周免疫细胞可通过血脑屏障并介导和参 与中枢神经炎症的调节，影响AD病程进展。本文将阐述T淋巴细胞及其亚群与AD疾病发展之间的相关 性和研究进展，并概述AD的主要治疗药物与炎症相关性。

Alzheimer’s disease (AD) is a neurodegenerative disease. Neuroinflammation is a key factor affecting the progression of AD. In recent years, a number of studies have identified the infiltration of peripheral T lymphocytes and their subsets in the brain parenchyma of AD patients, which confirmed that peripheral immune cells can cross the blood-brain barrier and participate in the regulation of central neuroinflammation, affecting the progression of AD. In this review, we will describe the research progress on the correlation between T lymphocytes, their subsets and the development of AD, and summarize the correlation between inflammation and the main therapeutic drugs for AD.