目的：调查女性帕金森病（PD）患者剂末现象（WO）的临床特征和危险因素。方法：采用横断面研究， 连续收集符合PD诊断标准的女性患者病例资料，收集一般人口学资料和临床数据（运动症状、非运动症 状、是否合并WO、服药情况等），并进行分析。结果：共收集女性PD患者146例，根据患者是否发生WO将 患者分为WO组63例（43.2%）和no-WO组83例。与No-WO组相比，WO组发病年龄更早、体质量和BMI 更低、病程更长、病情更重、每日左旋多巴等效剂量（LEDD）更大，更容易合并抑郁症（均P＜0.05）；多因素 Logistic回归分析提示，发病年龄大（OR=0.923，P=0.003）是女性WO的保护因素，而病程长（OR=1.256，P= 0.003）、H-Y分期高（OR=2.074，P=0.011）是WO的危险因素。结论：女性PD患者发生WO现象的危险因素 包括发病年龄小、病程长、H-Y分期高。

This study aimed to investigate the clinical characteristics and risk factors for the wearing-off (WO) phenomenon of Parkinson’s disease (PD) in female patients. Methods: In this cross-sectional study, we continuously collected the clinical data of female patients who met the PD diagnostic criteria. General demographic and clinical data, including motor symptoms, non-motor symptoms, possible combination with WO, and drug-related factors, were collected. Results: A total of 146 female patients with PD were enrolled and divided into the WO group (n=63 cases, 43.2% ), and the no-WO group (n=83 cases). Compared with the no-WO group, the WO group had an earlier age of onset , lower body weight and BMI, longer disease duration, more severe disease, higher Levodopa Equivalent Daily Dose (LEDD), and a greater risk of complication with depression (all, P<0.05). Multivariate logistic regression analysis revealed that older age at onset (OR=0.923, P= 0.003) was a protective factor for WO in female patients, while longer disease duration (OR=1.256, P=0.003) and higher Hoehn and Yahr (H-Y) stage (OR=2.074, P=0.011) were risk factors for WO. Conclusion: The risk factors of the WO phenomenon in female patients with PD include young age at onset, longer disease duration, and high H-Y stage.