目的：系统评价颈动脉支架成形术后高灌注综合征（CHS）的发生率及危险因素。方法：于2023年1月 26日检索Pubmed、Cochrane、Embase、Web of Science、中国生物医学文献数据库、中国知网、万方数据和中国 科技期刊数据库中有关颈动脉支架成形术后 CHS 的病例对照研究和横断面研究。采用 R4.2.1 和 Review Manager 5.3进行Meta分析。结果：共纳入14篇文献，3313例患者。Meta结果示，颈动脉支架成形术后CHS 发生率为 10.0%（95% CI 6%-14%）。糖尿病史 [OR=2.54，95% CI(1.64, 3.95)，P＜0.0001]、重度狭窄[OR= 20.69，95%CI(1.15, 370.72)，P=0.04]、术前脑血管反应性[OR=24.53，95%CI(16.51, 32.55)，P＜0.00001]、后循 环支架[OR=2.96，95% CI(1.31, 6.68)，P=0.009]是颈动脉支架成形术后CHS的危险因素。结论：颈动脉支架 成形术后CHS发生率较高。合并糖尿病、重度狭窄、术前脑血管反应性和后循环支架置入是颈动脉支架成 形术后CHS的重要危险因素。在为这些患者群体计划实施手术及围术期护理时，应充分考虑以上因素。

To systematically evaluate the incidence and risk factors of cerebral hyperperfusion syndrome (CHS) after carotid artery stenting. Methods: We retrieved risk factors from eight major databases for case-control studies and cross-sectional studies of CHS after carotid artery stenting in Jan 26, 2023, including Pubmed, Cochrane Library, Embase, Web of Science, China Biomedical Literature Database, China Knowledge Network, Wanfang Data, and Chinese Science and Technology Journal Database. The meta-analysis was performed using R4.2.1 and Review Manager 5.3. Results: A total of 3313 samples were searched and 14 studies were included. Meta-analysis results showed that the incidence of CHS after carotid artery stenting was 10.0% (95% CI 6%-14% ). History of diabetes [OR=2.54, 95% CI(1.64, 3.95), P<0.0001], severe stenosis [OR=20.69, 95% CI(1.15, 370.72), P=0.04], preoperative cerebrovascular reactivity [OR=24.53, 95% CI(16.51, 32.55), P< 0.00001] and rear circulation bracket [OR=2.96, 95% CI(1.31, 6.68), P=0.009] were risk factors for CHS after carotid artery stenting. Conclusion: The meta-analysis showed a higher incidence of CHS after carotid artery stenting. Previous history of diabetes mellitus, severe stenosis, preoperative cerebrovascular reactivity and rear circulation bracket are important risk factors for CHS after carotid artery stenting. These factors should be fully considered in perioperative care for these patient groups.