目前较多研究已揭示帕金森病（PD）运动症状的病理生理机制及治疗，然而针对其非运动症状 （NMS）的形成机制及用药较有限，并且多数患者在确诊前早已出现未受关注的NMS。近年来，国内外研 究发现5-羟色胺（5-HT）与PD-NMS及治疗用药之间存在密切联系。本文就目前常见的NMS与5-HT之 间的关系及治疗用药进行综述。

More studies have revealed the pathophysiological mechanisms and treatment of motor symptoms in Parkinson's disease (PD), but the mechanisms and medications for non-motor symptoms (NMS) are more limited, and most patients develop unattended NMS long before diagnosis. In recent years, domestic and international studies have identified a strong link between 5-hydroxytryptamine (5-HT) and PD-NMS and the medication used to treat it. In this paper, we review the current relationship between NMS and 5-HT and its therapeutic use.