星形胶质细胞是中枢神经系统分布最广泛的一类细胞，具有神经支持、维持血脑屏障稳定、调节脑脊液 循环及参与神经炎症等功能。研究表明，星形胶质细胞具有极强的昼夜节律，并参与自身功能的调节。本文 总结了昼夜节律紊乱对星形胶质细胞功能的影响，重点讨论昼夜节律紊乱情况下，内淋巴循环障碍、神经元氧 化应激与炎症、神经递质代谢异常以及突触功能改变，及其与神经退行性疾病之间的可能存在的联系。

Astrocytes are the most widely distributed cells in the central nervous system, which have the functions of neuronal transmission, nerve support, maintaining the stability of blood-brain barrier, regulating endolymphatic circulation and nerve inflammation. Recent studies have shown that circadian rhythms are involved in the regulation of these functions. Circadian rhythm disorder of astrocytes can lead to disturbance of endolymphatic circulation, abnormal accumulation of neurotransmitters and pro-inflammatory mediators, this in turn leads to impaired cognitive function and rhythm disorder.