视神经脊髓炎谱系疾病（NMOSD）是中枢神经系统的自身免疫性脱髓鞘疾病。越来越多的证据表 明，脂质代谢与NMOSD的不良临床疾病活动相关。在这篇综述中，我们总结了低密度脂蛋白（LDL）、高密 度脂蛋白（HDL）、甘油三酯（TG）与NMOSD活动性的相关性。虽然NMOSD的疾病活动性与脂质代谢异 常之间的因果关系尚未阐明，但我们认为，这一研究领域的进展有可能提高对视神经脊髓炎病理生理学的 理解，并确定新的治疗目标和策略。

Neuromyelitis optica spectrum disorders (NMOSD) is an autoimmune demyelinating disease in the central nervous system. There is increasing evidence that lipid metabolism is associated with adverse clinical disease activity in NMOSD. In this review, we summarized the correlation between low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and NMOSD activity. Although the causal relationship between disease activity in NMOSD and abnormal lipid metabolism has not been elucidated, we believe that advances in this area of research have the potential to improve understanding of the pathophysiology of neuromyelitis optica and identify new treatment targets and strategies.